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Other less common symptoms can sometimes include painful muscle spasms, dysphasia (difficulty speaking), mental retardation, facial grimacing, dysarthria (poorly articulated speech), and visual impairment. Methadone can be a synthetic Opioid and has been used as a part of an Opiate substitution regimen. The standard remedies are nerve blocks, therapy and medications. Neurotransmitter reuptake inhibitors such as SSRI's, SNRI's and Tricyclics also recommended. Treatment should be started as quickly as possible after symptoms start.
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